Kei's paper on using a riboswitch to control vesicular stomatitus virus (VSV) vector is now published in ACS Synthetic Biology
in which he demonstrated multiple cycles of ON/OFF gene regulation up to 12 days.
Welcome to our new technician, Mayumi.
Mohammed's work on histamine-responsive riboswitch and artificial cells is published in Journal of the American Chemical Society
(see OIST press release
). This was a great collaboration with the Matsuura group
at Osaka University who prepared and characterized beautiful liposomes containing our riboswitch!
Farewell to Mohammed and Dhamodharan, two of the original members of our Unit at OIST. Best of luck to both!
Shungo and Yoko's work on RNA molecular machine published in Nucleic Acids Research
. Covered in an OIST news story
with a cute artwork.
New JSPS KAKENHI grants awarded to Keisuke, Kei, Mohammed, Yoko, and Yohei.
Welcome to our new postdoc Vyankat Sontakke!
Goodbye and good luck to Kinuko who completed her internship and returned to Tokyo to finish her Ph.D.!
Yohei wrote a short review on applications of high-throughput sequencing to ribozyme investigations in Methods
Mohammed's new paper in ACS Synthetic Biology
demonstrates an exceptional ON/OFF ratio (3900) of gene expression by amplifying riboswitch response.
Welcome to Kinuko, a research intern from Tokyo who will be working with us for two months.
Welcome back to Gear who will start his thesis project in our unit!
We were awarded a JSPS Challenging Research (Exploratory) grant to develop chemically responsive artificial cells.
Dhamodharan (with Yoko and Mohammed) synthesized a photocaged guanine to control gene expression by light. The paper is now online at Chemical Communications
Keisuke joins as a new postdoc, and Aleksandra will spend this term in our unit as a rotation student!
Shungo's work on HDV-like ribozyme is now online at ACS Synthetic Biology
New Year brings new members
to the lab. Takeshi starts his thesis research, Bidesh rotates with us for the term, Keisuke from Osaka University starts his 9-week internship, and Narae joins as a new postdoc.
Yoko and Hsiao-Chiao's paper now online at Chemical Communications
. Direct screening for riboyzme activity in mammalian cells.
Shungo won the "Leading Initiative for Excellent Young Researchers" (卓越研究員) award from JSPS and started his program in industry. Best wishes to Shungo who spearheaded our deep sequencing projects!
Our first paper in ACS Chemical Biology
by Dhamodharan and Shungo is about quantitative kinetic measurement of thousands of deoxyribozyme mutants by deep sequencing.
Mohammed's work highlighted in OIST News Center
New academic year brings many new faces: Laura joins as new technician, Gear and Charles as rotation students, and Dalmira is back to stay for thesis project.
Mohammed's paper on controlling gene expression in a predatory bacterium called Bdellovibrio bacteriovorus
is now online in ACS Synthetic Biology
Welcome to our rotation students for the Spring term: Mai and Hsiao-Chiao.
Shungo and Kei's work on new pistol ribozymes was published in ACS Synthetic Biology
Welcome to our rotation student for the Winter term, Takeshi.
Welcome to Dalmira who is doing a rotation this term with us.
Shungo's work on twister ribozyme was published in Angewandte Chemie
(Open Access)!. We generated and assayed 10,296 single and double mutants of a twister ribozyme by deep sequencing.
Welcome to our first OIST rotation student, Kamila Mustafina.
Kei Takahashi joined our group as a postdoc.
Our new group members
have arrived at OIST.
We are finally in Okinawa!
Shungo's paper titled "High-throughput assay and engineering of self-cleaving ribozymes by sequencing" was published Nucleic Acids Research
. We used high-throughput sequencing to assay >1000 ribozyme variants at once.
Farhima's RNA amplifier circuit paper
We are moving to Okinawa Institute of Science and Technology
(OIST) in Okinawa, Japan in Summer 2015 to establish Nucleic Acid Chemistry and Engineering Unit
. The new Unit will build on the current research programs focusing on RNA engineering while expanding the scope to study chemistry and biological applications of nucleic acids in general. OIST also runs an international graudate program with full financial support. Interested propective students should refer to their graduate program website
OIST campus (OIST/Ginter)
Our research group is interested in the study of nucleic acids such as DNA and RNA to understand their chemistry and biology as well as to engineer nucleic acids with interesting and sophisticated functions in vitro, in devices, and in living cells.