Nucleic Acid Chemistry and Engineering

Photo: OIST
What's New
6/15/2020 Welcome to Nao who has started as a new technician.

4/1/2020 Congratulations to Narae for her KAKENHI grant!

1/18/2020 We welcome two new members at the start of the new year! Arriving with a fresh Ph.D. from Germany, Samuel is our new microbiologist. Shiv is our new research intern from the UK who will work with us for about six months.

12/11/2019 Congratulations to Kamila for her first paper published in ACS Synthetic Biology!. With some help from Keisuke, she engineered and analyzed the tandem aptamer-ribozyme fusion architecture as mammalian riboswitches.

11/14/2019 Mohammed's histamine aptamer was turned into a sensor for detecting food poisoning (published in Scientific Reports) !.

9/24/2019 Yatzu started her first rotation with us. Welcome!

9/2/2019 Yohei coedited the annual Synthetic Biology section in Current Opinion in Chemical Biology with Prof. Hirohide Saito at Kyoto University, focusing on mammalian synthetic biology. Check out 9 reviews including one on mammalian riboswitches written by Yohei.

8/27/2019 Yoko's work on minimizing an RNA ligase ribozyme using deep sequencing is now online in Nucleic Acids Research. Such small ribozymes may resemble ancient catalysts in the RNA world.

8/26/2019 Good luck to Laura who is leaving Okinawa to pursue her Ph.D. in Europe.

8/16/2019 Kei's paper on using a riboswitch to control vesicular stomatitus virus (VSV) vector is now published in ACS Synthetic Biology in which he demonstrated multiple cycles of ON/OFF gene regulation up to 12 days.

7/9/2019 Welcome to our new technician, Mayumi.

6/18/2019 Mohammed's work on histamine-responsive riboswitch and artificial cells is published in Journal of the American Chemical Society (see OIST press release). This was a great collaboration with the Matsuura group at Osaka University who prepared and characterized beautiful liposomes containing our riboswitch!

5/23/2019 Farewell to Mohammed and Dhamodharan, two of the original members of our Unit at OIST. Best of luck to both!

5/11/2019 Shungo and Yoko's work on RNA molecular machine published in Nucleic Acids Research. Covered in an OIST news story with a cute artwork.

4/1/2019 New JSPS KAKENHI grants awarded to Keisuke, Kei, Mohammed, Yoko, and Yohei.

4/1/2019 Welcome to our new postdoc Vyankat Sontakke!

3/25/2019 Goodbye and good luck to Kinuko who completed her internship and returned to Tokyo to finish her Ph.D.!

2/14/2019 Yohei wrote a short review on applications of high-throughput sequencing to ribozyme investigations in Methods.

2/2/2019 Mohammed's new paper in ACS Synthetic Biology demonstrates an exceptional ON/OFF ratio (3900) of gene expression by amplifying riboswitch response.

1/17/2019 Welcome to Kinuko, a research intern from Tokyo who will be working with us for two months.

9/18/2018 Welcome back to Gear who will start his thesis project in our unit!

8/6/2018 We were awarded a JSPS Challenging Research (Exploratory) grant to develop chemically responsive artificial cells.

5/31/2018 Dhamodharan (with Yoko and Mohammed) synthesized a photocaged guanine to control gene expression by light. The paper is now online at Chemical Communications.

5/1/2018 Keisuke joins as a new postdoc, and Aleksandra will spend this term in our unit as a rotation student!

1/19/2018 Shungo's work on HDV-like ribozyme is now online at ACS Synthetic Biology.

1/17/2018 New Year brings new members to the lab. Takeshi starts his thesis research, Bidesh rotates with us for the term, Keisuke from Osaka University starts his 9-week internship, and Narae joins as a new postdoc.

Older news/announcements

Our research group is interested in the study of nucleic acids such as DNA and RNA to understand their chemistry and biology as well as to engineer nucleic acids with interesting and sophisticated functions in vitro, in devices, and in living cells. The group started in the Department of Biomedical Engineering at University of California, Davis (UC Davis) in 2004, and moved to Okinawa Institute of Science and Technology Graduate University (OIST) in July 2015.

Last updated 6/23/2020